Not hard at all
There are some horror stories saying running ethanol through your fuel system just once will start deteriorating some components. Others have been doing it for years with no issue. I think the bottom line is determining how 'experimental' you are comfortable being, until you can verify with the maker that each and every part of your fuel system is ethanol tolerant. This would probably be hard due to liability concerns.
AFP fuel injection is tolerant of all fuels including pure ethanol.
The rest is up to you.
Your fuel tanks are ethanol tolerant.
Your fuel lines are ethanol tolerant, both aluminum and teflon lined hoses, whichever you decide to use.
If you don't trust the mechanical fuel pump, install dual electric pumps.
EFFI and AFP pumps are tolerant to ethanol fuel.
You do need to change the rubber o ring on the tank drains,
I bought 100 viton rings from Mcmaster for less than $5.-
That's about it.
Ethanol alters the vapor pressure significantly, which can cause vapor lock, especially on hot days and with winter fuel blends. One reason that some people use 100LL in one tank for takeoff/landing.
Ethanol is the octane booster in mogas and lowers your vapor pressure as well as increasing your margin for detonation as a result of the octane boost.
Vapor lock can very easily be designed out of your fuel system by either installing a constant flow return line or using dual electric fuel pumps.
No need to blame mogas for vapor lock.
Like Dan said, cars are designed for it and you are the designer of your fuel system, if you want to be. As I pointed out, all the components are easily available and widely use in airplanes. No reason at all to think you are rolling the dice.