Being a little anxious....
I agree with a lot of what has been said already. After 3600 or so hours, I am aware of being slightly anxious before nearly every flight. It isn't a fear so much as an awareness of the responsibility necessary to do what I am about to do. It is more of a respect for the airplane and the process of flying. It, in no way, distracts from the amazing feeling I have EVERY time I go flying. If someday I thought that I really knew how to fly an airplane, I'd stop flying.
Of the 33 years I have volunteered at OSH, all but about 8 or 9 trips there have been flying. I am anxious about every flight. I have flown my 1946 J-3 Cub, a Howard DGA, a Cessna 180, a Rangemaster and, of course SuzieQ, my RV-4. In all of those 1800 mile round trips, I have had one minor mechanical problem with a sometimes sticking valve in the Cub that was quickly fixed by Cy Galley and his excellent maintenance crew at OSH. So: in all those hours, including time in much older airplanes than I am old, no real mechanical issues. The Cub has to be propped to be started so no issues there. She can occasionally give me grief when warm but usually starts on the first blade.
Have I turned back or been delayed by weather? Oh, yeah! Plenty of times. The Fog Wall that seems to reside on the Colorado/Nebraska border is an issue on occasion and I've had to turn back and try the next day. I have diverted a lot due to weather, much easier in SuzieQ as she goes so much faster. I have landed the Cub in a field to let the weather go by more than once. As a friend of mine would say: Time to spare? Go by air. More time yet? Go by jet.
You just don't mess with Mother Nature.
This is part of the Flying Adventure. I have some amazing stories and have met some amazing people landing where I was not planning to go. One trip to OSH in the Cub I couldn't beat the Sunset so stopped in Portage, WI. As I was putting my tent up, a guy came by and asked if I wanted to put my Cub and myself in his hangar for the night. Well, yeah! He had come to the airport just to see if someone needed his hangar. I sat in the open door of the hangar and watched a huge thunder storm tear OSH up, damaging some airplanes on its way through. Just one of a multi-storied flying career.
It isn't the destination; it's the journey. Your logbook will be filled with memories of the flights you take. It is a Magic Carpet that will lead you on some of the most amazing adventures of which people who don't fly would have no idea. Flying is a special talent for multiple reasons. Be anxious; if it feels right: go. If it doesn't: don't go. We ALL have those stories.
Enjoy yourself and the talent you have. And your airplane......