The answer is, of course, it depends.
In this case, it all depends on where you are and where you're going.
Example: Yesterday, I returned from BZN to IAH. It took about 8 hr via Conti-Ted (my name for the merged airline) from the time I arrived at BZN until I got to my car at IAH. Let's factor that I actually live a LOT closer to LBX and there's an hour drive, so let's call it 9 hours.
You'd be hard pressed to beat that in the fastest of RVs, particularly given the weather along the front range yesterday. Plus, I got to sit FDH in my seat and catch up on some reading (never get time to read) and have a beverage that is prohibited while serving as PIC. $250 one-way is cheaper than GA for sure. This says nothing of the IAH-PDX run I often do (4 hr direct).
Winner: Big Iron
Example 2: Run to Dallas for the weekend. Going commercial, it requires a one hour drive to the airport, one hour for TSA Freedom Fondle and queuing up like cattle, er, self-loading cargo, one hour flight = 3 hours. $150 one-way short notice ticket. Even in the LSA-speed CT, it was about a 2 hour flight, direct to my destination, and it used about 10 gal of cheap 91 octane pump gas.
Winner: GA
So its all about mission and schedule for the airlines. GA gives you point-to-point ability and schedule flexibility (I'm sure Louise will be here soon to talk about her commute). Big Iron gives you better weather-coping ability, better speed over long distances, and the ability to sit not have to be PIC for 12 hours. You pays your $$ and you makes your choice.
YMMV,
TODR