I think it depends on how you want to have your paint look when you are done. Some people paint parts and then rivet them on with the rivets showing. They want that look. I didn't want to see any rivet heads. I did paint some pieces that are removable earlier on just to finish the piece. For the most part I waited as long as I thought I could. I held off installing things like the fuel vent lines, brakes & rudder pedals, air vent hoses, and the electrical.
I used the same paint combo as you are planning Azko primer and Jetflex. I scuffed the Azko with maroon scotchbrite and wiped it down with a tack cloth prior to shooting the interior. Mine actually came out pretty good. I did basically one side of the plane at a time. I climbed into the cabin and shot one side. Then I did the floor. Once that was all dry I climbed back in and shot the other side. I couldn't quite reach across the cabin and do it all in one go.
There is quite a bit of masking that is needed once you get the to be painted surfaces prepped. I mostly masked the firewall, but I wanted to paint the angle stiffeners for example. I painted doubler pieces on the firewall as well so they have to be masked around. It look quite a while to get this all completed. I painted the back pieces of the baggage area separately, but this meant I had to mask the opening that remained. Then while you are painting the interior you don't want overspray on the exterior sides or aft portion of fuselage. I taped cardboard pieces to the exterior to stop the over spray. It's quite a process.