For me....
WFO RPM and MP all the way to top of climb, leaning for TO EGT as altitude increases.
WO throttle, oversquare low RPM cruise, LOP.
Generally, cruise power settings (RPM, MP and mixture) all the way to the pattern.
Engine goes leaner on decent, cooling heads.
Occasionally increase mixture if lean fire limit reached (stumble).
Occasionally pull throttle back at about 3000 MSL as approaching pattern at low altitude airports if I have richened mixture for stumble.
So.
Everything firewall forward on TO. Engine monitor already set to show EGT peaks.
Climb. Casually observe EGT and adjust mixture as peaks go negative.
Top of climb reduce RPM to desired power level.
Finish LOP mixture setting.
Cruise.
Decend. No power change. Enjoy the speed. Your % power indication will go up but it is false because you are also going further LOP at same time.
Richen mixture only if you have to because the engine is complaining.
Reduce throttle only if power level is higher than you want it at that point in decent. Usually happens to me between 2 and 3000 MSL.
My home base pattern is 3200 ft. MSL