Telex Stratus 50-D
A good set of ANR headsets makes quite an improvement in your comfort in an RV.
Everyone seems to like what they bought (you better after spending upwards of $700) and I don't know anyone who has put 5 or 6 in the plane and gone up to compare them all. There is an article in this month's Private Pilot magazine on headsets, but it wasn't very specific in the comparisons between them.
I personally have a Telex Stratus 50-D and love them. They're a little heavier than some, but I don't notice it even after a long flight. The ear cups are thick memory foam and fit over glasses well. If you wear glasses when flying and the earcups don't seal well, all the ANR in the world isn't going to help you. My only complaint would be that the mic seems to pick up more background noise after breaking squelch than my david clark H10-13.4, but I probably just need to adjust the mic sensitivity down a bit from the present setting. I hasn't bothered me enough to actually do something about it yet!
They are built to last and I haven't had any issues in the 100hrs I've been using mine. (I seem to see a lot of reports of broken plastic on the lightspeed, even though the company will fix them)
One other note... I bought an ANR head set from another company for $300-400 and they were terrible. You get what you pay for.
I'd be curious to hear from someone who has tried some of the new, lightweight in-the-ear models. On hot days in the summer, not having a traditional headset on your head would be nice, even if they're not as quiet.
Whatever you order, make sure you can return them if you don't like them.
-Clay