The Wing's the Thing
Pierre,
Good lesson here in wing design. I'd venture to say that what you're seeing is mostly related to differences in the wing design between the two planes. And of the design differences, the added aspect ratio the RV10 has will no doubt make a difference in cruise drag numbers.
Aspect ratio is defined as the wing span squared, divided by the area:
A = b^2 / S
It plays a major role in how induced drag (Cd_i) is produced by the wing - that's the drag due to producing lift. An often used expression for Cd_i is:
Cd_i = Cl^2 / pi / A
Note the effect changing aspect ratio would have on the induced drag. Even though Cd_i is diminished at cruise, it still plays a significant role in the overall drag picture for the airplane. The wing is the biggest drag producer we have.
Now for the difference in wing design for the 6 and the 10:
RV6 Aspect Ratio = 23^2 / 110 = 4.8
RV10 Aspect Ratio = 31.75^2 / 148 = 6.8
The RV10 has 42% more aspect ratio than the RV6, which will drive the induced drag values down, relative to the total drag the airplane sees in flight.
Ok, so why the difference at altitude? You probably know that induced drag increases as airspeed decreases. At high altitude, the airplane is operating at much lower indicated airspeeds - lower dynamic pressure - which requires the wing to operate at a higher CL to offset the weight of the airplane.
So, when looking at the total drag picture on the airplane, induced drag is a greater factor at higher altitudes than when flying down low. The RV10's wing handles this issue much better than the short wing the RV6 has, and you're seeing the difference in performance.
There may also be significant propeller differences between the two planes, and the RV10 has an airfoil that's light years ahead of the old NACA 5-digits we have on most RV's. Pure size differences really do not play a role here.