I have used the AFS primer on my empennage and have been fairly well pleased. Actually, I was very pleased with how my rudder skins came out. But, then again, I guess that is what practice will do for you.
I really only see two down sides to using AFS. 1) you need to etch the parts. The AFS etch is water based, so once the etch is done and the part is rinsed, the part must be dry before priming. This obviously isn't very hard to do, but it is additional process time. 2) Cure time. If you apply a thinner coat, it will cure fairly fast, though I prefer to let it cure overnight. However, if you go heavy, it may take a long time. As in 3 days long. So, the lesson here is: 3 light coats like the AFS guys say.
The upshot is that it is pretty tough once it is cured. The only thing that has taken it off was a beating with the flush rivet set while riveting. Oops.
Otherwise, it has withstood reassembly and the day-to-day shuffling around the shop with no problems. It has also stood up to the occasional stray bucking bar very well. I do cheat and tape the edges of my bucking bars for just this sort of event, so the results may have been different if I didn't use the tape.
Personally, I haven't found the odor to be particuarly foul. Keep in mind, though, that I have done all of my priming outside. I would recommend you do the same.
If you do decide to give it a try, do be sure to buy the Dupont viscosity cup and thin the primer down to 18 seconds. I have found this to be important for obtaining a nice smooth finish. Well, that and filtering like the instructions say.
All in all, it looks great once it's applied. I expect will continue to use it for the rest of the build.
Cheers,
Robert