Many are also due to modification of the fuel system. Do NOT modify your fuel system unless A) you really do know what you're doing, B) you have a specific reason to modify your fuel system, C) you are using a proven modification, AND D) it is thoroughly tested.
Even with all of the above done, many problems with fuel systems won't rear their ugly heads until atmospheric pressure is reduced (i.e. in a climb). Also unproven modifications need to be tested in all attitudes.
Many times, changes to the fuel system aren't very apparent. Switch to perhaps a larger engine... you've modified your fuel system (read Fate is the Hunter, second to last chapter). Re-route a single fuel line because you've added a component or changed something else... you've modified your fuel system (An aircraft that is no longer in service).
Think it out thoroughly have it designed, cross-checked and tested before making critcal modifications. You can't be too careful.
Jerry