poly resin
Poly resin should not be bonded to plexi. If the plexi is well protected, for example with plastic or foil tape, there should be no issues. I have done several Pitts windshields where the attach strip was done with poly and bondo. It was drilled in place, then separated from the windshield for finishing and painting, then final assembly with machine screws. Well over 20 years on one with no issues.