Assuming that the specific question can even be answered, there are a few other constraints to add in, like winds aloft and other potential weather difficulties, fuel availability, and perhaps even TFRs. These can all delay or even make a particular destination impossible in the optimal sequence.
All this suggests that finding a useable, robust route might be a better real-world solution.
In other words, treat the problem like an engineering problem ("Get it good enough and press on," as Mark Drela put it) rather than as a scientific problem, where a theoretical state of perfection is the goal.