Bob,
When laying out your panel there are a lot of things to consider. I'm sure I'm not telling you anything new there.
Back when I set mine up, I elected to lay it out based on what I like to call "phase of flight" rather than function. Thus, all my lights are not grouped together.
Basic instrument layout is up high in the panel so the transition from looking at the instruments to outside is not that great. The Garmin 496 is in an AirGizmo angled adapter at the top of the radio stack so I don't have to look down to see it. The backup airspeed indicator is in the upper left hand corner of the panel, right where I look when landing. Think about those things when laying out your panel.
I started by putting paper cutouts on the blank panel and then putting that right in front of my weight machine so I could look at it every day while working out. A number of things were moved around while I had the "paper tiger" mock up.
Switch placement was a big deal for me. Nothing fancy on the stick like a starter button. Airplanes, even tail draggers, have been around for a long time without such things. Also think about future maintenance when laying out your panel. There is nothing worse than building something only to find out you can't change a switch later on.
Back to that "phase of flight" thing.
The most critical phase of any flight is landing, so start there. I put the carb heat just to the left of the throttle quadrant. To the left of that is fuel pump switch, and to the left of that is the landing light. Just to the right of the quadrant is the flap switch. I can rest my hand on the quadrant, push all the levers forward, including the carb heat, and toggle the flaps up with my fingers for a "go around".
To the right of all that are the dimmer switch, interior lights, and CB's. Non-critical stuff over there out of the way.
Starting the plane is easy enough. On the very left side is the split Cessna master switch, to the right of that are the two mag switches, then the starter button. (No key for me.) Then there is the avionics master, strobes, position lights, taxi light, landing light, fuel pump, etc. A simple starting sequence.
Keep in mind, my plane is a day/night VFR ship.
As for warning lights, I have a Dynon D100 EFIS and D10 EMS. Those two units put both a red warning bar across the bottom of both screens if something goes out of bounds AND a tone in your headset. Thus, I felt there was no need for an additional warning light.
However, I did put a green "fuel pump on" light at the top center of the panel. This will get my attention if the pump is not on when I start my take off roll or if I leave it on after switching tanks in flight.
That should give you an idea of one guy's thought process when laying out his panel.
One other thought, with the radios to the right of center, the D10 EMS fits just to the right of the right rib, almost directly in front of the co-pilot's position. With the ability to interconnect the D100 EFIS and D10 EMS, the co-pilot can have their own flight instruments and I can have the flight instruments and engine instruments displayed on my side.
Good luck with your panel layout. Remember to lay it out the way YOU want. This is where you personalize the plane and make it yours!
For more details on my panel and thoughts, check out this page:
http://www.repucci.com/bill/instruments.html