It is worth the trouble to try and nail down the reason for the deflation, because given the wrong set of circumstances, it could ruin your day and ruin the day of some other folks. There are two likely sources, the valve itself, or the tube and valve stem. I had a tire go flat in flight on another type of airplane, and it was because there was a problem with the valve. Unless you check carefully when replacing the valve after a tire change, you may leave a small leak. I made a tool many years ago to check the tightness of the valve itself. Valve caps specifically for aircraft act as a double seal for the stem, just in case there is a leak at the valve. Those of us who use a stem extension to check tire pressure can't easily put a cap on, and can't easily tell if the valve is leaking (with a little spit on the top). I like the suggestion from the guy who said that he leaves the airplane overnight after checking tire pressure. Good idea, but you can't always wait. If your problem is with the with tube or valve stem, it could be caused by low initial pressure. It is prossible for the tire to rotate on the rim. Or, it could be a design problem in the tube itself. I have a car with tire pressure monitoring, and there is a big "why not" in my mind for tire pressure monitoring in our RVs.