If it were me, I would not use anything that reciprocates to cut the panel, especially if it is already painted.
The method I would use is:
Mark and outline the area to be cut with tape. (Masking tape, etc.)
Drill the corners with a #40 or #30 drill bit, inside the corners.
Use a cutting wheel on a dremel or die grinder. I like to use the reinforced cut off discs for the dremel.
Carefully scribe along your line with the cut off, but do not cut all the way through the metal on the first pass. This will cut the paint and some of the metal. Use a second or third pass to cut through the metal completely. Be careful at the corners. You could do all four sides before you actually cut completely to the corners,
Make sure you cut inside of the line you have drawn and taped.
Follow up with a fine tooth file. File toward the painted surface. If you file back toward you, as you look at the painted side, you will probably chip off pieces of the powder coat.
When you remove the tape, pull it toward the cut and the chances of pulling up a chip of paint will be lessened. (If you pull it away from the cut edge, you may pull up a piece of edge paint.)
Wear goggles and hearing protection and take your time in doing this and you will get great results. The radio will most likely overlap the edge by a little bit and cover any imperfections you may create, but you should be able to make it almost perfect, if you take your time.
I have used this method successfully and it works for me.
Regardless of the method you end up using, good luck.