I can't answer all your questions definitively but some of them I can. My setup uses high-tension leads to automotive plugs for the LSE ignitions. However:
1 & 6. Never mix electrical and hydraulic/pneumatic (fuel/oil/etc) routing.
2. They can but be sure to allow for engine movement. The coils for my 'right' LSE (actually the bottom plugs) are attached to the engine mount as there is no good spot on the engine to mount them. 10 years and no problem with those wires.
3. No. Plug wires should not be routed with any other wires. Maintain at least 1/2" separation. Plug wires can be bundled together and, at least for the high-tension wires, hot rod suppliers sell 'combs' to organize your plug wires.
4. Pretty far. For instance, my right-hand lower plugs run free from the engine mount. Here is the
Kitlog entry with a photo. Using the LSE gave me the luxury of making my own custom leads, so I could use straight connectors for the lower plugs and 90-degree connectors elsewhere plus custom length, which segues into your
5. As long as it isn't vibrating and rubbing on anything, either should be Ok, though you will probably be happier if the wires are not stretched to make your routing. Easier visual is not that important; if the routing is secure you are mainly interested in the connections.
Like I said, my setup is slightly different than standard aircraft wires but other than the flexibility I had for planning it mostly holds true.