If you're looking for a more scenic route; I think this one would be pretty fun to fly if you're a fan of desert landscape (I am!).
Make your way down the CA valley hugging the Sierra Nevadas, then cut east to Mojave, on to Phoenix, and then towards El Paso. Fly down through the Big Bend area (Marfa) and along the Rio Grande to Del Rio (great low level route goes through there; VR1108, one of my favorites in UPT--however I'd only do it on the weekend when they aren't flying

). Continue east through San Antonio along to the gulf coast area of Louisiana and continue hugging the coast all the way to Ft Myers.
If I had more time; I'd probably head down the CA coast a little more rather than through the valley to enjoy some better scenery (weather dependent of course; as you well-know the west coast sure gets fogged-in from time to time

).
