Ron
Do you have a datalog of the engine monitor.
Send it to me by email if you do.
Couple of things in no particular order that have caused rough running in RV10/IO540's
1. Fuel pump temperature causing vapour bubbles, and as these go through the engine will run rough. richer does not always fix it, although the extra fuel flow means the volume of fuel spends less time in the lines and less chance of heating up. Constant battle down here in summer even with the fuel pump cooling shroud. (although we have tried to improve airflow just this week, time will tell).
2. Plugs....many variables but I have seen this time and time again. Folk and in particulare LAME's (A&P's) seem to disregard this critical thing. If massive electrodes, set between 16-18 thou, do not let them get past 22 thou.
3. Inlet Gaskets. Don't ask me how we know

Brand new engine installed and at 230 hrs 5 out of 6 gaskets were cracked, some considerably. Go looking for fuel stains around the inlet tubes and the gasket to head interface. Check all bolts/nuts on your inlet and exhaust flanges. You may well have a couple failing.
4. When you see any rough running, before you break out in a terrified sweat, and preferably while LOP turn a mag off and watch it for 10 seconds, note any changes then do the other. Very helpful in finding plugs, wires and maggies that are faulty.